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Changsha Jiekai Biological Products Co., Ltd.
Contact Phone:
86-0731-82287663
86-0731-82284663
Fax number:
86-0731-82284663
Zip Code: 410016
Address: Room 2505, Block A, East County Huacheng Plaza, No. 166, Section 1, Wanjiali Middle Road, Changsha City, Hunan Province
Products Name:
Magnolia Bark Extract
Latin name:
Magnolia officinalis
Plant part used:
Magnolol &. Honokiol
Specification:
2%, 3%, 5% Magnolol, 50%, 90%, 95% Magnolol+Honokiol
Testing methods:
HPLC
CAS No:
528-43-8, 35354-74-6
Main functions:
Anti-tumorigenic and Anti-cancer, Anti-anxiety, Anti-thrombolytic, Reduce allergic and asthmatic rea
Classification:
Component Monomers
Key words:
Herbal Database
Describe
Brief Introduction
Synonyms--- Hou Po (Chinese:厚朴), Houpu magnolia, Magnolia obovata (Japanese species), Magnolia grandifloris
Magnolol, Dehydrodichavicol
Chemical Name: 4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol; 5,5'-Diallyl-2,2'-biphenyldiol 5,5'-Diallyl-2,2'-dihydroxybiphenyl
CAS No.: 528-43-8
Molecular Formula: C18H18O2
Mol. Wt.: 266.334
Molecular Structure:
Honokiol, Houpa, HNK
Chemical Name: 2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol
CAS No.: 35354-74-6
Molecular Formula: C18H18O2
Mol. Wt.: 266.334
Molecular Structure:
Magnolia is a large genus of about 210 flowering plant species in the subclass Magnolioideae of the family Magnoliaceae.
The natural range of Magnolia species is a disjunct distribution, with a main center in east and Southeast Asia and a secondary center in eastern North America, Central America, the West Indies, and some species in
The genus is named after French botanist Pierre Magnol.
Magnolia is an ancient genus. Having evolved before bees appeared, the flowers developed to encourage pollination by beetles. As a result, the carpels of Magnolia flowers are tough, to avoid damage by eating and crawling beetles. Another primitive aspect of Magnolias is their lack of distinct sepals or petals.
The bark from M. officinalis has long been used in traditional Chinese medicine, where it is known as hou po (厚朴). In
Magnolia has attracted the interest of the dental research community because magnolia bark extract inhibits many of the bacteria responsible for caries and periodontal disease. In addition, the constituent magnolol interferes with the action of glucosyltransferase, an enzyme needed for the formation of bacterial plaque.
Early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as Houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark.
Magnolol is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis). It is known to act on the GABAA receptors in rats, as well as having antifungal properties.
Honokiol exists naturally with its structural isomer magnolol, which differs from honokiol only by the position of one hydroxyl group. Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.
The Magnolia Bark Extract (Magnolol and Honokiol) used in dietary supplements and for medicine uses is derived from the bark of the plant Magnolia officinalis.
Benefits
•Anti-anxiety
• Potent and Highly Tolerable Anti-tumorigenic Effects (Honokiol)
•Anti-depression and Anxiolytic Effects (Honokiol)
• Act on the GABAA receptors (Magnolol)
• Neurotrophic (Honokiol)
• Antifungal, Anti-bacerial (Inhibit bacteria responsible for caries and periodontal disease) (Magnolol and Honokiol)
• Anti-thrombotic Effects (Honokiol)
•Reduce allergic and asthmatic reactions (Magnolol and Honokiol)
• Anti-emetic Effects (Honokiol)
Mechanism
Anti-tumorigenic activities: Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.
Neurotrophic activity: Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.
Anti-thrombolytic activity: Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotein injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.
Safety
Magnolia Bark Extract (Magnolol and Honokiol) is safe.
Dosage
• Consult physicians for different condition specifics.
GNI’s Magnolia Bark Extract (Magnolol and Honokiol) Features and Benefits:
Magnolia Bark Extract (Magnolol and Honokiol) is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Magnolia officinalis bark.
• High purity: over 95%
• NO solvent - residual free
• Pesticide-free
• Grey-white to
• High anti-bacteria, and longer shelf life
Product Specifications:
50%, 90%, 95% Magnolol+Honokiol HPLC
2%, 3%, 5% Magnolol (with natural ratio of Honokiol) HPLC
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