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Changsha Jiekai Biological Products Co., Ltd.
Contact Phone:
86-0731-82287663
86-0731-82284663
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86-0731-82284663
Zip Code: 410016
Address: Room 2505, Block A, East County Huacheng Plaza, No. 166, Section 1, Wanjiali Middle Road, Changsha City, Hunan Province

Products Name:

Magnolia Bark Extract


Magnolia Bark Extract
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  • Magnolia Bark Extract

Latin name:

Magnolia officinalis

Plant part used:

Magnolol &. Honokiol

Specification:

2%, 3%, 5% Magnolol, 50%, 90%, 95% Magnolol+Honokiol

Testing methods:

HPLC

CAS No:

528-43-8, 35354-74-6

Main functions:

Anti-tumorigenic and Anti-cancer, Anti-anxiety, Anti-thrombolytic, Reduce allergic and asthmatic rea


Classification:

Component Monomers

Key words:

Herbal Database

Consult

Describe


Brief Introduction

Synonyms--- Hou Po (Chinese:厚朴), Houpu magnolia, Magnolia obovata (Japanese species), Magnolia grandifloris

Magnolol, Dehydrodichavicol

Chemical Name: 4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol; 5,5'-Diallyl-2,2'-biphenyldiol 5,5'-Diallyl-2,2'-dihydroxybiphenyl

CAS No.: 528-43-8
Molecular Formula: C18H18O2

Mol. Wt.: 266.334

Molecular Structure:

Honokiol, Houpa, HNK

Chemical Name: 2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol

CAS No.: 35354-74-6
Molecular Formula: C18H18O2

Mol. Wt.: 266.334

Molecular Structure:

Magnolia is a large genus of about 210 flowering plant species in the subclass Magnolioideae of the family Magnoliaceae.

The natural range of Magnolia species is a disjunct distribution, with a main center in east and Southeast Asia and a secondary center in eastern North America, Central America, the West Indies, and some species in South America.

The genus is named after French botanist Pierre Magnol.

Magnolia is an ancient genus. Having evolved before bees appeared, the flowers developed to encourage pollination by beetles. As a result, the carpels of Magnolia flowers are tough, to avoid damage by eating and crawling beetles. Another primitive aspect of Magnolias is their lack of distinct sepals or petals.

The bark from M. officinalis has long been used in traditional Chinese medicine, where it is known as hou po (厚朴). In Japan, kōboku, M. obovata has been used in a similar manner. The aromatic bark contains magnolol and honokiol, two polyphenolic compounds that may have demonstrated anti-anxiety and anti-angiogenic properties. Magnolia bark also may have been shown to reduce allergic and asthmatic reactions.

Magnolia has attracted the interest of the dental research community because magnolia bark extract inhibits many of the bacteria responsible for caries and periodontal disease. In addition, the constituent magnolol interferes with the action of glucosyltransferase, an enzyme needed for the formation of bacterial plaque.

Early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as Houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark.

Magnolol is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis). It is known to act on the GABAA receptors in rats, as well as having antifungal properties.

Honokiol exists naturally with its structural isomer magnolol, which differs from honokiol only by the position of one hydroxyl group. Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.

The Magnolia Bark Extract (Magnolol and Honokiol) used in dietary supplements and for medicine uses is derived from the bark of the plant Magnolia officinalis.

Benefits

Anti-anxiety

• Potent and Highly Tolerable Anti-tumorigenic Effects (Honokiol)

•Anti-depression and Anxiolytic Effects (Honokiol)

• Act on the GABAA receptors (Magnolol)

• Neurotrophic (Honokiol)

• Antifungal, Anti-bacerial (Inhibit bacteria responsible for caries and periodontal disease) (Magnolol and Honokiol)

• Anti-thrombotic Effects (Honokiol)

Reduce allergic and asthmatic reactions (Magnolol and Honokiol)

• Anti-emetic Effects (Honokiol)

Mechanism

Anti-tumorigenic activities: Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.

Neurotrophic activity: Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.

Anti-thrombolytic activity: Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotein injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.

Safety

Magnolia Bark Extract (Magnolol and Honokiol) is safe.  

Dosage

• Consult physicians for different condition specifics.

GNI’s Magnolia Bark Extract (Magnolol and Honokiol) Features and Benefits:

 Magnolia Bark Extract (Magnolol and Honokiol) is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Magnolia officinalis bark.

• High purity: over 95%

• NO solvent - residual free

• Pesticide-free

• Grey-white to Crystal white in appearance

• High anti-bacteria, and longer shelf life

Product Specifications:

50%, 90%, 95% Magnolol+Honokiol HPLC

2%, 3%, 5% Magnolol (with natural ratio of Honokiol) HPLC

Immediately Consult