All categories


Time of issue:2020-02-25 00:00:00
Address: Room 1106, #13-3 Chang Fang Dong Jun,#111 East RenMin Anvenue, Changsha,Hunan, 410016, China

Lappaconitine Hydrobromide, Aconitum leucostomum Extract

Number of views:

Lappaconitine Hydrobromide, Aconitum leucostomum Extract

Retail price
Market price
Number of views:
Product serial number
Latin name:
Aconitum leucostomum Extract
Plant part used:
Lappaconitine Hydrobromide (Allapinin)
96%, 98%, 99% HPLC
Testing methods:
Main Function:
Antiarrythmic Effect, Anti-addiction analgesic Effect

Brief Introduction

Synonyms---Aconite, Aconitum leucostomum, Aconitum lycoctonum Aconitum Sinomontanum, monkshood, wolf's bane, leopard's bane, women's bane, Devil's helmet or blue rocket, Lappaconitine Hydrobromide, Allapinin

Lappaconitine Hydrobromide, Allapinin, Allapinine

Chemical Name: ACONITANE-4,8,9-TRIOL, 20-ETHYL-1,14,16-TRIMETHOXY-, 4-(2-(ACETYLAMINO)BENZOATE), Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-(acetylamino)benzoate), monohydrobromide, (1-alpha,14-alpha,16-beta)-, Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethyoxy-, 4-(2-(acetylamino)benzoate), monohydrobromide, (1alpha,14alpha,16beta)-

CAS NO.: 97792-45-5
Molecular Formula: C32H44N2O8·HBr·H2O

Mol. Wt.: 665.65

Molecular Structure:


Aconitum known as aconite, monkshood, wolf's bane, leopard's bane, women's bane, Devil's helmet or blue rocket, is a genus of over 250 species of flowering plants belonging to the buttercup family (Ranunculaceae). Aconitum leucostomum is a species of the genus Aconitum, native to Europe and northern Asia. It is a herbaceous perennial plant growing to 1 m tall. The leaves are palmately lobed with four to six deeply cut lobes. The flowers are 18–25 mm long, dark violet, rarely pale yellow. Like all species in the genus, it is poisonous.

Aconite has long been used in the traditional medicine of Asia (India, China). Activated Aconite is used as an herb in Chinese traditional medicine, including in a formula to treat Arthritis. It exhibits especially potent analgesic properties, according to a recent study conducted by researchers with the Department of Anesthesiology, Perioperative and Pain Medicine at Harvard Medical School. Their research reveals that one of the active ingredients in aconite–Bulleyaconitine A, or BLA– strongly reduces sodium channel currents to block overactive pain signals for prolonged periods of time. In China, BLA has been approved for the treatment of chronic pain and rheumatoid arthritis.

In Western medicine preparations of aconite were used until just after the middle of the 20th century. Internal uses were pursued, to slow the pulse, as a sedative in pericarditis and heart palpitations, and well diluted as a mild diaphoretic, or to reduce feverishness in treatment of colds, pneumonia, quinsy, laryngitis, croup, and asthma due to exposure. Taken internally, aconite acts very notably on the circulation, the respiration, and the nervous system. The pulse is slowed, the number of beats per minute being actually reduced, under considerable doses, to forty, or even thirty, per minute. The blood-pressure synchronously falls, and the heart is arrested in diastole. Immediately before arrest, the heart may beat much faster than normal, though with extreme irregularity, and in animals the auricles may be observed occasionally to miss a beat, as in poisoning by veratrine and colchicum. The action of aconitine on the circulation is due to an initial stimulation of the cardio-inhibitory centre in the medulla oblongata (at the root of the vagus nerves), and later to a directly toxic influence on the nerve-ganglia and muscular fibres of the heart itself. The fall in blood-pressure is not due to any direct influence on the vessels. The respiration becomes slower owing to a paralytic action on the respiratory centre and, in warm-blooded animals, death is due to this action, the respiration being arrested before the action of the heart. Aconite further depresses the activity of all nerve-terminals, the sensory being affected before the motor. In small doses, it therefore tends to relieve pain, if this is present. The activity of the spinal cord is similarly depressed. The pupil is at first contracted, and afterwards dilated. The cerebrum is totally unaffected by aconite, consciousness and the intelligence remaining normal to the last. The antipyretic action which considerable doses of aconite display is not specific but is the result of its influence on the circulation and respiration and of its slight diaphoretic action.

Both Chinese medicine and Ayurveda have methods of processing aconite to reduce its toxicity. In Chinese medicine, the traditional pao zhi or preparation of aconite is to steam it with ginger in a fairly elaborate procedure. Due to the variable levels of toxicity in any given sample of the dried herb, there are still issues with using it. Most but not all cases of aconite toxicity in Taiwan were due to the consumption of unprocessed aconite. According to an article by the Indian scientists Thorat and Dahanukar, "Crude aconite is an extremely lethal substance. However, the science of Ayurveda looks upon aconite as a therapeutic entity. Crude aconite is always processed i.e. it undergoes 'samskaras' before being utilized in the Ayurvedic formulations. This study was undertaken in mice, to ascertain whether 'processed' aconite is less toxic as compared to the crude or unprocessed one. It was seen that crude aconite was significantly toxic to mice (100% mortality at a dose of 2.6 mg/mouse) whereas the fully processed aconite was absolutely non-toxic (no mortality at a dose even 8 times as high as that of crude aconite). Further, all the steps in the processing were essential for complete detoxification".

Lappaconitine Hydrobromide (Allapinin) is made from Aconitum leucostomum with less or no toxicity, it is pharmaceutically used as Antiarrythmic and analgesic (anti-addiction) medicines with strong efforts, and it also can be used as the specific antiarrythmic medicines and local anesthesia, refrigeration, anti-inflammation and detumescence. It is broadly used to treat, gastroenteritic ulcer, gastritis, hepatitis, cholecystitis, rheumatism, sciatica, toothache, etc.


• Antiarrythmic Effect

• Anti-addiction analgesic Effect (Relieve pain)

• Local anesthesia Effect

Refrigeration Effect

Anti-inflammation Effect

Detumescence. Effect


Referring to the above information.


Referring to the above information.


Consulting the physicians.

GNI’s Features and Benefits:

Lappaconitine Hydrobromide, Aconitum leucostomum Extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Aconitum leucostomum roots.

•  Produced with pure water only

•  High purity: over 98%

•  NO solvent - residual free

•  Pesticide-free

•  Crystal white in appearance, and tasteless.

•  High solubility in water

•  High anti-bacteria, and longer shelf life

Scan the QR code to read on your phone
We could not find any corresponding parameters, please add them to the properties table

Product Search

Plant extracts product index(Alphabetical index):0~9 | A | B | C | D | E | F | G | H | I | J | K | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Other

Plant extracts Product Index (by product name name):Hot Products | Herbal Extracts | Standardized Extracts | Component Monomers | Index by Function | OEM | Function Formula

Plant extracts Product Index (index by product efficacy farmers):Index by Function | Herb Database | Contracting Manufacturin



Copyright: © 2010-2015 Gentcare Natural Ingredients, Inc. 湘ICP备案10010904号
Address:Room 1106, #13-3 Chang Fang Dong Jun, #111 East RenMin Anvenue, Changsha, Hunan, 410016, China

Powered by www.300.cn