Brief Introduction

Synonyms--- Triperygium wilfordii, Lei Gong Teng, Thunder God Vine, Three-wing Nut

Triptolide, PG490, Triptolid

Chemical Name: Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one, 3b,4,4a,6,6a, 7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-
Molecular Formula: C20H24O6

Mol. Wt.: 360.4

Molecular Structure:  

Tripterygium wilfordii Hook. f. (Celastraceae) is a perennial vine growing in southern China. The herb, also called Lei Gong Teng (Thunder God Vine or "three-wing nut")--Deciduous scandent shrub, twigs brown, angular, and downy. Leaves ovate to elliptic, 5-15 cm long, 2,5-7 cm wide, light green glabrous above, paller, very glaucous and pubescent on nerves beneath. Margin crenate, apex pointed. Small whitish flowers with 5 petals about 9 mm across, in terminal panicles in July. Fruit 3-winged, about 1,5 cm long, brown-red.

It has been used in Chinese medicine for treatment of fever, edema, and carbuncles for centuries. The powdered roots of the plant were also used as an insecticide. Over the last 30 years it has been used in the treatment of rheumatoid arthritis, chronic nephritis, chronic hepatitis, thrombocytopenia, ankylosing spondylitis, and skin diseases.

Constituents: Triptolide, Wilforlide A, Celastrol, and etc.

The Lei Gong Teng Extract is derived from the roots of the plant Tripterygium wilfordii Hook. f.

Benefits

• Treat Rheumatoid Arthritis (RA)

• Treat Fever

• Treat Edema

• Treat Carbuncles

• Treat Chronic Nephritis

• Treat Chronic Hepatitis

• Treat Thrombocytopenia

• Treat Ankylosing Spondylitis

• Treat Skin Diseases

• Treat leiomyoma, tumor and Anti-cancer

• Using as Insecticide

Mechanism

Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study.

Tao X, Younger J, Fan FZ, Wang B, Lipsky PE.
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA.
OBJECTIVE: To examine the safety and efficacy of an extract of Tripterygium wilfordii Hook F (TWHF) in the treatment of patients with rheumatoid arthritis (RA).

METHODS: An ethanol/ethyl acetate extract from the roots of TWHF was prepared and used in a prospective, double-blind, placebo-controlled study in patients with longstanding RA in whom conventional therapy had failed. Patients were randomly assigned to receive either placebo or low-dose (180 mg/day) or high-dose (360 mg/day) extract for 20 weeks, followed by an open-label extension period. Clinical responses were defined as 20% improvement in disease activity according to the American College of Rheumatology criteria. Side effects were actively queried and recorded at each visit. RESULTS: A total of 35 patients were enrolled in the trial; 21 patients completed the 20-week study. One patient from each group withdrew because of side effects. Twelve, 10, and 10 patients in the placebo, low-dose, and high-dose groups, respectively, completed at least 4 weeks of treatment. Of these patients, 8 and 4 in the high-dose and low-dose groups, but none in the placebo group, met criteria for clinical response. Four, 4, and 7 patients in the placebo, low-dose, and high-dose groups, respectively, were enrolled in the open-label extension; of these, 2, 4, and 5 patients, respectively, met criteria for clinical response. The most common side effect was diarrhea, which caused 1 patient in the high-dose group to withdraw from the trial. No patients withdrew because of adverse events during the open-label extension.

CONCLUSION: The ethanol/ethyl acetate extract of TWHF shows therapeutic benefit in patients with treatment-refractory RA. At therapeutic dosages, the TWHF extract was well tolerated by most patients in this study.

Safety

Warning: The raw roots have toxins that require careful processing to remove. You are strongly advised not to experiment with the raw roots yourself.

Dosage

Consult physicians for different condition specifics.

GNI’s Lei Gong Teng Extract Features and Benefits:

Lei Gong Teng Extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Tripterygium wilfordii Hook. f. roots.

• High purity: over 98%

• NO solvent - residual free

• Pesticide-free

• Crystal white in appearance

• High anti-bacteria, and longer shelf life

Product Specifications:

Triptolide 0.1-1.0% HPLC  (ethanol/ethyl acetate extract)

Triptolide 5.0%-10.0% HPLC (ethanol/ethyl acetate extract)

Wilforlide A  0.1%-1.0% HPLC (ethanol/ethyl acetate extract)

Triptolide 98% min HPLC

Wilforlide A 98% min HPLC

Celastrol 98% min HPLC

Lei Gong Teng Tablet Material (Comply with CP criteria: 0.1% min. Wilforlide A)  雷公藤多甙片原料药（符合中国药典（部颁标准, 雷公藤内酯甲≥0.1%）