Brief Introduction

Synonyms--- Japanese Honeysuckle, White Honeysuckle, Chinese Honeysuckle, Jin Yin Hua (Chinese: 金银花), Lonicera

Chlorogenic Acid

Chemical Name: (1S,3R,4R,5R)-3-{[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy} -1,4,5-trihydroxycyclohexanecarboxylic acid
Molecular Formula: C₁₆H₁₈O₉

Mol. Wt.: 354.31

Molecular Structure:

Chlorogenic acid is a family of naturally occurring organic compounds. These are esters of cinnamic acids and (-)-quinic acid. It is an important biosynthetic intermediate. It also is one of the phenols found in Green Coffee Bean, in Eucommia ulmoides leaf, Honey Suckle Flower, in the bamboo Phyllostachys edulis as well as many other plants. This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal. Structurally, chlorogenic acid (CGA) is the ester formed between caffeic acid and (L)-quinic acid (1L-1(OH), 3, 4/5-tetrahydroxycyclohexanecarboxylic acid). Isomerization of chlorogenic acid have been reported with 3 isomerizations of the quinic acid in position 3 (3-CQA), 4 (4-CGA) and 5 (5-CQA). Isomerisation at position 1 has not yet been reported. This acid is an important intermediate in lignin biosynthesis. Chlorogenic acid is marketed under the tradename Svetol in Norway and the United Kingdom as a food active ingredient used in coffee, chewing gum, and mints to promote weight reduction.

Honeysuckles (Lonicera, syn. Caprifolium Mill.) are arching shrubs or twining vines in the family Caprifoliaceae, native to the Northern Hemisphere, mainly in China. Widely known species include Lonicera periclymenum (European Honeysuckle or Woodbine), Lonicera japonica (Japanese Honeysuckle, White Honeysuckle, or Chinese Honeysuckle) and Lonicera sempervirens (Coral Honeysuckle, Trumpet Honeysuckle, or Woodbine Honeysuckle). Hummingbirds are attracted to these plants because they have sweetly-scented, bell-shaped flowers that produce sweet, edible nectar, thus it is named honeysuckles. The name Lonicera stems from Adam Lonicer, a Renaissance botanist.

The fragrant yellow flowers of this plant are used in herbal medicine around the world for cleansing, consuming, digesting, and stimulating circulation to remove inflammation. Honeysuckle Flowers are used as a kind of tea drink for more than 2000 years in Japan and China. In Traditional Chinese Medicine, honeysuckle flowers are among the important herbs for clearing heat and relieving toxicity. It relieves "fire toxicity" manifesting itself as hot, painful sores or swellings of the eyes, throat, or breast. It expels "wind-heat" manifesting itself as sore throat or headache after explore to cold. And it treats "damp heat" manifesting itself as bladder infection. Modern laboratory research has confirmed that the flowers have an inhibitory effect on the bacteria that cause salmonella, staph, strep, pseudomonas, and tuberculosis infections.

The dried flowers, harvested just before the bud opens contain abundant phenolic natural compounds as Chlorogenic Acid, Inositol, luteolin, tannins.

The Chlorogenic Acid used in dietary supplements is derived from the leaves of Eucommia ulmoides, Green Coffee Bean and Honey Suckle Flower.

Benefits

• Antioxidant

• Anti-diabetes

• Anti-tumor

• Weight Reduction

• Antibacterial

•Diminish inflammation

•Detoxification

•Decrease Cholesterol absorption

•Lower blood pressure

•Stimulate leukocyte

•Accelerate gastrointestinal peristalsis

•Promote excrete of gastric juice

Mechanism

Chlorogenic acid is an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of Type 2 Diabetes Mellitus and cardiovascular disease. It is claimed to have antiviral, antibacterial and antifungal effects with relatively low toxicity and side effects, alongside properties that do not lead to antimicrobial resistance. Potential uses are suggested in pharmaceuticals, foodstuffs, feed additives, and cosmetics.

It has been proven in animal studies in vitro to inhibit the hydrolysis of the enzyme glucose-6-phosphatase in an irreversible fashion. This mechanism allows chlorogenic acid to reduce hepatic glycogenolysis (transformation of glycogen into glucose) and to reduce the absorption of new glucose. In addition, in vivo studies on animal subjects have demonstrated that the administration of chlorogenic acid lessens the hyperglycemic peak resulting from the glycogenolysis brought about by the administering of glucagon, a hyperglycemiant hormone. The studies also confirmed a reduction in blood glucose levels and an increase in the intrahepatic concentrations of glucose-6-phosphate and of glycogen.

Safety

Green Coffee Bean Extract and Chlorogenic acid is safe. It is claimed to have antiviral, antibacterial and antifungal effects with relatively low toxicity and side effects, alongside properties that do not lead to antimicrobial resistance. Potential uses are suggested in pharmaceuticals, foodstuffs, feed additives, and cosmetics.

Do not use Chlorogenic aic products when there is chronic diarrhea caused by cancer treatment, HIV, hepatitis C, or other chronic disease.

Dosage

• The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).
• Consult physicians for different condition specifics.

GNI’s Chlorogenic acid Features and Benefits:

Chlorogenic acid is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Green Coffee Bean, Eucommia ulmoides leaves, Honey Suckle Flower.

• Produced with pure water only

• High purity: over 99%

• NO solvent - residual free

• Pesticide-free

• Crystal white in appearance

• High solubility in water

• High anti-bacteria, and longer shelf life

Product Specifications:

· 5%-99% Chlorogenic acid HPLC