Brief Introduction

Synonyms--- White mulberry

Kuwanon G (Kuwanone G, Kuwanon, kumanon G, 4H-1-Benzopyran-4-one)

Chemical Name: 8-[(1S, 5R, 6S)-6-(2, 4-dihydroxybenzoyl)-5-(2, 4-dihydroxyphenyl)-3- methylcyclohex-2-en-1-yl]-2-(2, 4-dihydroxyphenyl)-5, 7-dihydroxy-3-(3-methylbut-2-enyl) chromen-4-one

Molecular Formula: C40H36O11

Mol. Wt.: 692.71

Molecular Structure:

Morus alba, known as white mulberry (or Morus nigra, known as black mulberry, or other over 10 species), is a short-lived, fast-growing, small to medium sized mulberry tree, which grows to 10–20 feet tall. The species is native to northern China, and is widely cultivated and naturalized elsewhere. The white mulberry is widely cultivated to feed the silkworms for silk. Cultivation of white mulberry for silkworms began over four thousand years ago in China. In 2002, 6,260km2 of land were devoted to the species in China.

White mulberry leaves, spades shaped, are the preferred feedstock for silkworms, and are also cut for food for livestock (cattle, goats, etc.) in areas where dry seasons restrict the availability of ground vegetation. The leaves were also long used for medicinal purposes. The fruit is 1–2.5cm long; in the species in the wild it is deep purple, but in many cultivated plants it varies from white to pink; it is sweet but bland, unlike the more intense flavor of the red mulberry and black mulberry. The fruit are eaten, often dried or made into wine, and were used for medicinal purposes. The mulberry root barks, in traditional Chinese medicine name “Sang-Bai-Pi” (White Mulberry Root-Bark) are used for medicinal purposes.

In traditional Chinese medicine, the barks are used to treat cough, wheezing, edema, and to promote urination. It is also used to treat fever, headache, red dry and sore eyes, as well as cough. The root bark of Morus alba has been used as a traditional medicine in Asian countries and exhibits antibacterial activity against food poisoning micro-organisms. The active antibacterial constituent in the Mulberry root bark extract was identified as Kuwanon G. Studies show that the compound displayed preferential antimicrobial activity against cariogenic bacteria. Electron microscopic examination of S. mutans cells treated with kuwanon G indicated that the mode of antibacterial action was inhibition or blocking of cell growth, as treated cells showed a disintegrated surface and an unclear cell margin. Albanol A(1),isolated from the root bark extract of Morus alba may be a promising lead compound for developing an effective drug for treatment of leukemia. Moracin M , Steppogenin-4′-O-β-D-glucosiade , Mullberroside A were isolated from the root bark of Morus alba L. and all produced hypoglycemic effects. Mulberry roots Extract showed adaptogenic activity, indicating its possible clinical utility as an antistress agent.

The White Mulberry Root-bark extract used in dietary supplements is derived from the root-barks of the plant mulberry trees (Morus alba L.).

Benefits

• Antibacterial effects;

• Treat leukemia;

• Hypoglycemic effects

• Adaptogenic activity

• Antistress agent;

Mechanism

Refer to the above information.

Safety

White mulbery root-bark extract is safe, no side effects have been reported to date, but relying on this type of treatment alone, and avoiding conventional medical care, may have serious health consequences.

Dosage

•  The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).
•  Consult physicians for different condition specifics.

GNI’s White Mulberry Root-Bark Extract Features and Benefits:

White mulberry root-bark extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Morus alba root-barks.

•  Produced with pure water only

•  High purity: over 10%

•  NO solvent - residual free

•  Pesticide-free

•  Brownish-Yellow in appearance

•  High solubility in water

•  High anti-bacteria, and longer shelf life

Product Specifications:

10% Kuwanon G HPLC,

5:1, 10:1, 20:1, 25:1