Andrographis Paniculata Extract

Brief Introduction

Synonyms--- Chuan Xin Lian 穿心蓮(Chinese), Kalmegh, Green Chirayta, Creat, King of Bitters, Andrographis, India Echinacea, and etc. (See below list)

Andrographolide

Chemical Name:3-[2-[decahydro-6-hydroxy-5- (hydroxymethyl)-5,8a- dimethyl-2- methylene-1- napthalenyl]ethylidene]dihydro- 4-hydroxy-2(3H)-furanone

Molecular Formula: C₂₀H₃₀O₅

Mol. Wt.:350.45 g/mol

Molecular Structure:

Andrographis paniculatais a herbaceous plant in the family Acanthaceae, native to China,India and Sri Lanka. It is widely cultivated in southern Asia, where it is used to treat infections and some diseases, often being used before antibiotics were created. Mostly the leaves and roots were used for medicinal purposes.

Andrographis paniculata is an erect annual herb extremely bitter in taste in each and every part of the plant body. It grows erect to a height of 30-110 cm in moist shady places with glabrous leaves and white flowers having rose-purple spots on the petals. Flowers are small, solitary in panicles. Fruit is approximately 2 cm long. Seeds are numerous, yellow-brown in colour. In many languages, it is named “king of bitters”, or “bitter of the earth” The genus Andrographis consists of 28 species of small annual shrubs essentially distributed in tropical Asia. Only a few species are medicinal, of which A. paniculata is the most popular. It has many common names for different language:

List of common names of A. paniculata Nees

Language    Common name 

Assamese   Chiorta

Arabic         Quasabhuva

Marathi        Oli-kiryata

Bengali        Kalmegh

Oriya           Bhuinimba

Chinese       Chuan Xin Lian 穿心蓮

English        Green chirayta, creat, king of bitters, andrographis, India echinacea

Persian        Naine-havandi

Gujarati        Kariyatu

Sanskrit       Kalmegha, Bhunimba

Hindi           Kirayat

Tamil           Nilavembu

Kannada      Nelaberu

Telugu         Nelavemaa or Nelavepu

Malayalam   Nilavembu, Kiriyattu

Indonesian   Sambiloto

Thai             Fa-Talai-Jorn

Sinhalese     Heen Kohomba, Heen Bim Kohomba

Since ancient times, A. paniculata is used in traditional Chinese and Ayurvedic systems of medicine as well as in tribal medicine in India and some other countries for multiple clinical applications.

Andrographis paniculataplant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract, is implicated in its pharmacological activity.

The therapeutic value of A. paniculata is due to its mechanism of action which is perhaps by enzyme induction. The plant extract exhibits antityphoid and antifungal activities.A. paniculata is also reported to possess antihepatotoxic, antibiotic, antimalarial, antihepatitic, antithrombogenic, antiinflammatory, anti-snake venom, and antipyretic properties to mention a few, besides its general use as an immunostimulant agent. A recent study conducted at Bastyr University, confirms the anti-HIV activity of andrographolide.

The herb is the well-known drug Kalmegh 'green chiretta', and forms the principal ingredient of a household medicine ('alui'), used as a bitter tonic and febrifuge. Andrographis Paniculata is used widely to treat fevers like chikenguinea, swine-flu, typhoid etc.

In one Chilean study, the herb had a significant drying effect on the nasal secretions of cold sufferers who took 1,200 milligrams of andrographis extract daily for five days.

Andrographolideis a water-soluble labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Andrographolide is an extremely bitter substance, the chief constituent extracted from the stem and leaves of the andrographis paniculata, which is grown for medicinal purposes in China and India. Andrographolide has been shown to be effective against certain cancers and is an effective purgative.

Andrographolide exhibits protective effects in carbon tetrachloride induced hepatotoxicity in rats. Its LD50 in male mice was 11.46gm/kg. The hepatoprotective action of andrographolide is related to activity of certain metabolic enzymes.

A study has been conducted on the cellular processes and targets modulated by andrographolide treatment in human cancer and immune cells. Andrographolide treatment inhibited the in vitro proliferation of different tumor cell lines, representing various types of cancers. These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.

The Andrographis paniculata Extract (Andrographolide)used in dietary supplements is derived from the aerial parts (mostly the leaves) of the plant Andrographis paniculata.

Benefits

•Immunostimulant Effects

•Anti-cancer

•Anti-bacterial

•Treat infections

• Anti-typhoid against Salmonella typhae

• Antifungal against Helminthosporium sativum

• Treat Flu, sinusitis, upper respiratory tract infection, cough and bronchitis

• Dispel heat and remove toxins

•Hepatoprotective Effects (Protect Liver)

• Treat Malaria

• Anti-HIV

Mechanism

The therapeutic value of A. paniculata is due to its mechanism of action which is perhaps by enzyme induction.

Safety

Andrographis paniculata Extract (Andrographolide)is safe; no side effects have been reported to date.

Dosage

• The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).
• Consult physicians for different condition specifics.

GNI’s Andrographis paniculata Extract (Andrographolide)Features and Benefits:

Andrographis paniculata Extract (Andrographolide)is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology fromAndrographis paniculata herb (mostly the leaves).

• Produced with pure water only

• High purity: over 95%

• NO solvent - residual free

• Pesticide-free

• Crystal white in appearance

• High solubility in water

• High anti-bacteria, and longer shelf life

Product Specifications:

5%, 30%, 95% Andrograpbolide HPLC