Brief Introduction

Synonyms--- Cimicifuga racemosa, Actaea racemosa L., Black cohosh, Black bugbane, Black snakeroot, Fairy candle

Triterpene glycosides (e.g. Cycloartane)

Chemical Name: Cycloorthane; 5α-Cycloartane; 9, 19-Cyclolanostane
Molecular Formula: C30H52

Mol. Wt.: 412.73

Molecular Structure:

Cimicifuga racemosa is a plant of the buttercup family (Ranunculaceae). Black cohosh is a smooth (glabrous), herbaceous perennial plant that produces large, compound leaves from an underground rhizome, reaching a height of 25–60 centimetres (9.8–24 in).It is native to eastern North America. The roots and rhizomes of black cohosh have long been used medicinally by Native Americans. Extracts from these plant materials are thought to possess analgesic, sedative, and anti-inflammatory properties. Today, black cohosh preparations (tinctures or tablets of dried materials) are used mainly to treat symptoms associated with menopause.

Native Americans used black cohosh to treat gynecological and other disorders, including sore throats, kidney problems, and depression. Following the arrival of European settlers in the U.S. who continued the medicinal usage of black cohosh, the plant appeared in the U.S. Pharmacopoeia in 1830 under the name “black snakeroot”. In 1844 A. racemosa gained popularity when Dr. John King, an eclectic physician, used it to treat rheumatism and nervous disorders. Other eclectic physicians of the mid-nineteenth century used black cohosh for a variety of maladies, including endometritis, amenorrhea, dysmenorrhea, menorrhagia, sterility, severe after-birth pains, and for increased breast milk production.

Black cohosh is used today mainly as dietary supplement marketed to women as remedies for the symptoms of premenstrual tension, menopause and other gynecological problems. However, its usage for treating these ailments is controversial, with some studies casting doubt on its efficacy. Study design and dosage of black cohosh preparations play a role in clinical outcome, and recent investigations with pure compounds found in black cohosh have identified some beneficial effects of these compounds on physiological pathways underlying age-related disorders like osteoporosis. According to some placebo-controlled studies that included a sufficiently high number of participants to determine statistical significance of clinical outcomes, the use of black cohosh appears to be safe, but ineffective for treating menopausal hot flashes.

Like most plants, black cohosh tissues and organs contain many organic compounds with biological activity. Estrogen-like compounds had originally been implicated in effects of black cohosh extracts on vasomotor symptoms in menopausal women. Several other studies, however, have indicated absence of estrogenic effects and compounds in black cohosh-containing materials. Recent findings suggest that some of the clinically relevant physiological effects of black cohosh may be due to compounds that bind and activate serotonin receptors, and a derivative of serotonin with high affinity to serotonin receptors, N_ω-methylserotonin, has been identified in black cohosh. Complex biological molecules, such as triterpene glycosides (e.g. cycloartanes), have been shown to reduce cytokine-induced bone loss (osteoporosis) by blocking osteoclastogenesis in in vitro and in vivo models.

The Black Cohosh Root Extract used in dietary supplements is derived from the roots of the plant black cohosh (Cimicifuga racemosa L.).

Benefits

• Treat symptoms associated with menopause

• Analgesic, sedative properties

• Anti-inflammatory properties

• Increase breast milk production

Mechanism

Not available.

Safety

Black Cohosh Extract is safe, no side effects have been reported to date, but relying on this type of treatment alone, and avoiding conventional medical care, may have serious health consequences.

Dosage

•  The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).
•  Consult physicians for different condition specifics.

GNI’s Black Cohosh Extract Features and Benefits:

Black cohosh Extact is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from roots of black cohosh (Cimicifuga racemosa L.).

•  Produced with pure water only

•  High purity: over 8%

•  NO solvent - residual free

•  Pesticide-free

•  Brown-Yellow in appearance

•  High solubility in water

•  High anti-bacteria, and longer shelf life

Product Specifications:

2.5%, 5%, 8%Triterpene Glycosides HPLC