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Changsha Jiekai Biological Products Co., Ltd.
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86-0731-82287663
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Zip Code: 410016
Address: Room 2505, Block A, East County Huacheng Plaza, No. 166, Section 1, Wanjiali Middle Road, Changsha City, Hunan Province

Products Name:

Ginkgo Biloba Leaf Extract


Ginkgo Biloba Leaf Extract
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  • Ginkgo Biloba Leaf Extract

Latin name:

Ginkgo Biloba L.

Plant part used:

Leaves

Specification:

24% Total Ginkgo Flavone Glycosides &. 6% Total Terpene Lactones, &.< 5ppm or <1ppm Ginkolic acid HP

Testing methods:

HPLC

CAS No:

90045-36-6

Main functions:

Benefit Brain Cardiovascular Health, Memory Support


Classification:

G

Key words:

Consult

Describe


Brief Introduction

Synonyms--- Ginkgo, Gingko, Maidenhair Tree

Ginkgo flavone glycosides ( including Kaempferol, Quercetin (Rutin), and isorhamnetin)

Chemical Name:
Molecular Formula:

Mol. Wt.:

Molecular Structure:

jk

R = H: kaempferol-3-O-rutinoside
R = OH: quercetin-3-O-rutinoside (rutin)
R = OCH3: isorhamnetin-3-O-rutinoside

Quercetin

CAS No.: 117-39-5

Chemical Name:4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)- 3,5,7-trihydroxy-(9CI)
Molecular Formula: C15 H10 O7

Mol. Wt.:338.3

Molecular Structure:

 

Kaempferol

CAS No.: 520-18-3

Chemical Name:4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4- hydroxyphenyl)-(9CI)
Molecular Formula: C15 H10 O6

Mol. Wt.:286.2

Molecular Structure:

jk

Isorhamnetin

CAS No.: 480-19-3

Chemical Name:4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4- hydroxy-3-methoxyphenyl)-(9CI)
Molecular Formula: C15 H12 O6

Mol. Wt.:~314

Molecular Structure:

jk

Ginkgolides (mixed); ginkgolide A; ginkgolide B
CAS Registry Number: 15291-77-7; 15291-75-5; 15291-75-5
Chemical Name:Not available
Molecular Formula: C20 H24 O10 (Ginkgolide B)

Mol. Wt.:424.4 (Ginkgolide B)

Molecular Structure:

jk

 

Compound Name

R1

R2

R3

Ginkgolide A

OH

H

H

Ginkgolide B

OH

OH

H

Ginkgolide C

OH

OH

OH

Ginkgolide J

OH

H

OH

Ginkgolide M

H

OH

OH

Bilobalide
CAS No.:33570-04-6

Chemical Name:4H,5aH,9H- Furo(2,3-b)furo(3',2':2,3)cyclopenta (1,2-c)furan-2,4,7 (3H,8H) -trione 9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-, (5aR-(3aS*,5aa,8b,8aS*,9a,10aa))- (9CI)

Molecular Formula:C15H18O8

Molecular Weight:326.3

Structure:

jk

Ginkgo(Ginkgo biloba; in Chinese and Japanese 銀杏, pinyin romanization: yín xìng), also spelled gingko, also known as the Maidenhair Tree, is a unique species of tree with no close living relatives. The ginkgo is classified in its own division, the Ginkgophyta, comprising the single class Ginkgoopsida, order Ginkgoales, family Ginkgoaceae, genus Ginkgo. Ginkgos are very large trees, normally reaching a height of 20–35 m (66–115 feet), with some specimens in China being over 50 m (164 feet). The tree has an angular crown and long, somewhat erratic branches, and is usually deep rooted and resistant to wind and snow damage. During autumn, the leaves turn a bright yellow, and then fall. A combination of resistance to disease, insect-resistant wood and the ability to form aerial roots and sprouts makes ginkgos long-lived, with some specimens claimed to be more than 2,500 years old. Ginkgo is the only extant species within this group. It is one of the best-known examples of a living fossil, because Ginkgoales other than G. biloba are not known from the fossil record after the Pliocene. Although Ginkgo biloba and other species of the genus were once widespread throughout the world, the tree currently occurs in the wild only in the northwest of Zhejiang province in the Tianmu Shan mountain reserve in eastern China, but even its status as a naturally occurring species there is questionable. In other areas of China it has been long cultivated and it is common in the southern third of the country. The tree is the national tree of China. It has also been commonly cultivated in North America for over 200 years, but during that time it has never become significantly naturalized.

The nut-like gametophytes inside the seeds are particularly esteemed in Asia, and are a traditional Chinese food. In Chinese culture, they are believed to have health benefits; some also consider them to have aphrodisiac qualities.

Ginkgo biloba leaf Extract (GBE) contains Ginkgo flavone glycosides and Terpene lactones, and have been used pharmaceutically. The flavone glycosides, such as keampferol, quercetin, isorhamnetin, have anti-oxidant and free radical properties. The ginkgolides, which are trilactonic diterpenes, include ginkgolide A, B, C. GBE is standardized to contain 24% Ginkgo flavone glycosides and 6% terpene lactones including Ginkgolide ABC and bilobalide. Ginkgosupplements are usually taken in the range of 40–200 mg per day.

Both the leaves and the seeds have been used in Traditional Chinese Medicine.This ancient remedy has been recommended for coughs, asthma and inflammations due to allergies. Today the clinical experience in China has focused on using tablets or injectable drug forms in the treatment of angina pectoris, chronic bronchitis, and its effect on lowering serum cholesterol levels.

The standardized extract of the leaves has been used extensively in Europe for two decades. Because of wide restorative effects, its excellent safety, also with the increasing population of the aged, the standardized extract of the leaves will surely have more and more important function for people's health and lives. In a study of mountain climbers on a Himalayan expedition, GBE was significantly more effective than placebo in preventing acute altitude sickness and cold-related vascular problems (Roncin et al., 1996). Also in a randomized, controlled, double-blind, German study, GBE was significantly superior to placebo in improving symptoms of intermittent claudication (a type of peripheral arterial disease that causes pain in the legs due to obstructed blood flow (Peters, 1998).Ginkgo leaf extract (GBE) is now among the leading prescription medicines in both France and Germany, where they account for 1.0 and 1.5 percent, respectively, of total prescription sales.

The Ginkgo biloba Leaf Extract used in dietary supplements is derived from the leaves of the plant Ginkgo biloba L..

Benefits

• Relieve symptomatic of organic brain dysfunction

Treat intermittent claudication

Treat Vertigo (vascular origin)

Treat Tinnitus (vascular origin)

Improve Blood Flow---- especially to capillaries in the brain & other extreme body.

Inhibit PAF

Act as a vasodilator

Stimulate prostacyclin production

Improve Oxygen & Glucose Supply----especially to the brain

Improve mental concentration & alertness (memory enhancement)

Improve Nerve Transmission----especially in the brain to improve memory & brain activity

Increase neurotransmitter activity to transmit nerve impulses

Promote Acetylcholing receptors in brain

Antioxidant Action----to protect brain, heart, lungs, eyes, ears, blood vessels & nerves against free-radical oxidative damage

Antimicrobial Action----to protect bronchial tubes & mucous membranes of the respiratory tract

Provide relief to asthma & bronchitis sufferers

Lower Cholesterol----To improve cardiovascular health

Prevents & Promotes Recovery From Stoke &/or Heart Attack

Improve Overall Brain-nerve-muscle Function.

Mechanism

Referring to the above information.

Safety

Ginkgo biloba Leaf Extract is quite safe, but when you take it, you should first consult a doctor.

Side effects

Ginkgo may have undesirable effects, especially for individuals with blood circulation disorders and those taking anticoagulants such as ibuprofen, aspirin, or warfarin, although recent studies have found that ginkgo has little or no effect on the anticoagulant properties or pharmacodynamics of warfarin in healthy subjects. Ginkgo should also not be used by people who are taking certain types of antidepressants (monoamine oxidase inhibitors and selective serotonin reuptake inhibitors) or by pregnant women, without first consulting a doctor.

Ginkgo side effects and cautions include: possible increased risk of bleeding, gastrointestinal discomfort, nausea, vomiting, diarrhea, headaches, dizziness, heart palpitations, and restlessness. If any side effects are experienced, consumption should be stopped immediately.

Allergic p

Immediately Consult