Brief Introduction

Synonyms---Gotu Kola, Luei Gong Gen(Chinese name), Asiatic Pennywort, Indian Pennywort, Takip-kohol, Antanan, Pegagan, Pegaga, vallaarai, Kula kud, Bai Bua Bok, Brahmi

Asiaticoside

Synonyms:Madecassol, Asiaticosid

Chemical Name:Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-.alpha.-L-mannopyranosyl- (1.fwdarw.4)-O-.beta.-D-glucopy ranosyl-(1.fwdarw.6)-.beta.-D-glucopyranosyl ester, (2.alpha., 3.beta.,4.alpha.)-
CAS Number:16830-15-2

Molecular Formula: C₄₈H₇₈O₁₉

Mol. Wt.:959.12

Molecular Structure:

Centella asiaticais a small herbaceous annual plant of the family Mackinlayaceae or subfamily Mackinlayoideae of family Apiaceae, and is native to China,India, Sri Lanka, northern Australia, Indonesia, Iran, Malaysia, Melanesia, Papua New Guinea, and other parts of Asia. Common names include Gotu Kola, Asiatic Pennywort, Indian Pennywort, Luei Gong Gen, Takip-kohol, Antanan, Pegagan, Pegaga, vallaarai, Kula kud, Bai Bua Bok, Brahmi (this last name is shared with Bacopa monnieri) and rau má (literally: mother vegetable- Vietnamese). In Assamese it is known as Manimuni. It is used as a medicinal herb in Ayurvedic medicine and traditional Chinese medicine. Botanical synonyms include Hydrocotyle asiatica L. and Trisanthus cochinchinensis (Lour.).In Telugu Language this is known as "Saraswathi Plant" in India.

The stems are slender, creeping stolons, green to reddish green in color, interconnecting one plant to another. It has long-stalked, green, reniform leaves with rounded apices which have smooth texture with palmately netted veins. The leaves are borne on pericladial petioles, around 2 cm. The rootstock consists of rhizomes, growing vertically down. They are creamish in color and covered with root hairs.The flowers are pinkish to red in color, born in small, rounded bunches (umbels) near the surface of the soil. Each flower is partly enclosed in two green bracts. The hermaphrodite flowers are minute in size (less than 3 mm), with 5-6 corolla lobes per flower. Each flower bears five stamens and two styles. The fruit are densely reticulate, distinguishing it from species of Hydrocotyle which have smooth, ribbed or warty fruit.

The crop matures in three months and the whole plant, including the roots, is harvested manually.

Medicinal effects

Gotu kola is a mild adaptogen, is mildly antibacterial, anti-viral, anti-inflammatory, anti-ulcerogenic, anxiolytic, a cerebral tonic, a circulatory stimulant, a diuretic, nervine and vulnerary.

When eaten raw as a salad leaf, pegaga is thought to help maintain youthfulness. In Thailand cups with gotu kola leaves are used as an afternoon pick me up. A decoction of juice from the leaves is thought to relieve hypertension. This juice is also used as a general tonic for good health. A poultice of the leaves is also used to treat open sores.

Richard Lucas claimed in a book published in 1966 (second edition in 1979) that a subspecies "Hydrocotyle asiatica minor" allegedly from Sri Lanka also called "Fo ti tieng", contained a longevity factor called 'youth Vitamin X' said to be 'a tonic for the brain and endocrine glands' and maintained that extracts of the plant help circulation and skin problems. However according to medicinal herbalist Michael Moore, it appears that there is no such subspecies and no Vitamin X is known to exist.Nonetheless some of the cerebral circulatory and dermatological actions claimed from centella (as hydrocotyle) have a solid basis.

Several scientific reports have documented Centella asiatica's ability to aid wound healing, which is responsible for its traditional use in leprosy. Upon treatment with Centella asiatica, maturation of the scar is stimulated by the production of type I collagen. The treatment also results in a marked decrease in inflammatory reaction and myofibroblast production.

The isolated steroids from the plant have been used to treat leprosy. In addition, preliminary evidence suggests that it may have nootropic effects. Centella asiatica is used to re-vitalize the brain and nervous system, increase attention span and concentration, and combat aging. Centella asiatica also has anti-oxidant properties. It works for venous insufficiency. It is used in Thailand for opium detoxification.

Benefits

Mildly antibacterial, anti-viral, anti-inflammatory, anti-ulcerogenic, anxiolytic,

Vulnerary Effects (Wound Healing Effects)

Cerebral tonic Effects

Circulatory stimulant Effects

Diuretic Effects

Nervine Effects

Mechanisms of action

Refer to the above introduction.

Safety, Adverse effects and unknowns

Gotu kola Extract (Asiaticoside) is safe. No side effects about using Gotu kola Extract (Asiaticoside) have been found.

Dosage

•  The typical dose is 500-1200mg per day (usually in 2-3 doses throughout the day).
•  Consult physicians for different condition specifics.

GNI’s Gotu kola Extract Features and Benefits:

 Gotu Kola Extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Centella asiaticaLwhole herb.

•  Produced with pure water only

•  High purity: over 40% Asiaticoside.

•  NO solvent - residual free

•  Pesticide-free

•  Crystal yellow to yellow-brown in appearance

•  High anti-bacteria, and longer shelf life

Product Specifications:

10%-40% Asiaticoside HPLC

10%-80% Total Triterpenes Glycosides HPLC