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Changsha Jiekai Biological Products Co., Ltd.
Contact Phone:
86-0731-82287663
86-0731-82284663
Fax number:
86-0731-82284663
Zip Code: 410016
Address: Room 2505, Block A, East County Huacheng Plaza, No. 166, Section 1, Wanjiali Middle Road, Changsha City, Hunan Province

Products Name:

Artemisia annua Extract, Wor


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Latin name:

Artemisia annua L.

Plant part used:

Leaf and Upper Portion

Specification:

99.5% Artemisnin, 99% Dihydroartemisinin,99% Artesunate, 99% Artemether

Testing methods:

HPLC

CAS No:

63968-64-9, 71939-50-9, 83507-69-1, 71963-77-4

Main functions:

Malaria treatment, Parasite treatment, Cancer treatment


Classification:

A

Key words:

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Synonyms--- Sweet Wormwood, Sweet Annie, Sweet Sagewort, Annual Wormwood, qīnghāo (Chinese: 青蒿) Artemisinin (Artemisinine, Qinghaosu) Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-octahydro-3,6,9-trimethyl -3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one Molecular Formula: C15H22O5 Mol. Wt.: 282.332 Molecular Structure: Dihydroartemisinin (DHA, Dihydroqinghaosu ) Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-decahydro-3,6,9-trimethyl-3,12- epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol Cas No.: 71939-50-9 Molecular Formula: C15H24O5 Mol. Wt.: 284.34806 Molecular Structure: Artesunate (AS) Chemical Name: / Cas No.: 83507-69-1, 80155-81-3 (sodium salt) Molecular Formula: C19H28O8 Mol. Wt.: 384.421 Molecular Structure: Artemether (It is an ether derivative of artemisinin.) Chemical Name: / Cas No.: 71963-77-4 Molecular Formula: C16H26O5 Mol. Wt.: 298.374 Molecular Structure: Artemisia annua, also known as Sweet Wormwood, Sweet Annie, Sweet Sagewort or Annual Wormwood, qīnghāo (Chinese: 青蒿), is a common type of wormwood that is native to temperate Asia, but naturalized throughout the world. It is primarily cultivated in south-west China now for medical uses. It has fern-like leaves, bright yellow flowers, and a camphor-like scent. Its height averages about 2 m tall, and the plant has a single stem, alternating branches, and alternating leaves which range 2.5–5 cm in length. It is cross-pollinated by wind or insects. It is a diploid plant with chromosome number, 2n=18. Artemisia annua was used by Chinese herbalists in ancient times to treat fever (not specifically malaria) and many other ills including malaria. In 1971, Chinese scientists demonstrated that the plant extracts had antimalarial activity in primate models, and in 1972 the active ingredient, artemisinin (formerly referred to as arteannuin), was isolated and its chemical structure described. Artemisinin may be extracted using a low boiling point solvent such as diethylether and is found in the glandular trichomes of the leaves, stems, and inflorescences, and it is concentrated in the upper portions of plant within new growth. Artemisinin (pronounced /ɑ?t?'misin?n/) is a drug used to treat multi-drug resistant strains of falciparum malaria. The compound (a sesquiterpene lactone) is isolated from the plant Artemisia annua. Not all plants of this species contain artemisinin. Apparently it is only produced when the plant is subjected to certain conditions, most likely biotic or abiotic stress. It can be synthesized from artemisinic acid. The drug is derived from a herb used in Chinese traditional medicine, though it is usually chemically modified and combined with other medications. Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization as there have been signs that malarial parasites are developing resistance to the drug. Combination therapies that include artemisinin are the preferred treatment for malaria and are both effective and well tolerated in patients. The drug is also being studied as a treatment for cancer. Because artemisinin itself has physical properties such as poor bioavailability that limit its effectiveness, semi-synthetic derivatives of artemisinin, including dihydroartemisinin, artemether and artesunate, have been developed. However, their activity is not long lasting, with significant decreases in effectiveness after one to two hours. To counter this drawback, artemisinin is typically given with lumefantrine (also known as benflumetol) to treat uncomplicated falciparum malaria. Lumefantrine has a half-life of about 3 to 6 days and prevents the disease from returning. The treatments are called "ACT" (artemisinin-based combination therapy); other examples are artemether-lumefantrine, artesunate-mefloquine, artesunate-amodiaquine, and artesunate-sulfadoxine/pyrimethamine. Recent trials have shown that these therapies are more than 90% effective, with a recovery from symptoms after three days, especially for the chloroquine-resistant Plasmodium falciparum. There are a number of derivatives and analogues (Chemically modified analogues) within the artemisinin family: ? Artesunate (water-soluble: for oral, rectal, intramuscular, or intravenous use) ? Artemether (lipid-soluble: for oral, rectal or intramuscular use) ? Dihydroartemisinin ? Artelinic acid ? Artenimol ? Artemotil There are also simplified analogs in preclinical research. Dihydroartemisinin (or dihydroqinghaosu) is a drug used to treat malaria. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS. Artemether is an ether derivative of artemisinin. It is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. The Artemisinin and its derivatives are derived from the leaf and the upper portions of Arteminsia annua L.

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