Mulberry Leaf Extract

Brief Introduction

Synonyms--- White mulberry, black mulberry

1-Deoxynojirimycin

Chemical Name: (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol
Molecular Formula: C₆H₁₃NO₄

Mol. Wt.: 163.17

Cas No.: 19130-96-2

Molecular Structure:

Morus alba, known as white mulberry (or Morus nigra, known as black mulberry, or other over 10 species), is a short-lived, fast-growing, small to medium sized mulberry tree, which grows to 10–20 feet tall. The species is native to northern China, and is widely cultivated and naturalized elsewhere. The white mulberry is widely cultivated to feed the silkworms for silk. Cultivation of white mulberry for silkworms began over four thousand years ago in China. In 2002, 6,260km2 of land were devoted to the species in China.

White mulberry leaves, spades shaped, are the preferred feedstock for silkworms, and are also cut for food for livestock (cattle, goats, etc.) in areas where dry seasons restrict the availability of ground vegetation. The leaves were also long used for medicinal purposes. The fruit is 1–2.5cm long; in the species in the wild it is deep purple, but in many cultivated plants it varies from white to pink; it is sweet but bland, unlike the more intense flavor of the red mulberry and black mulberry. The fruit are eaten, often dried or made into wine, and were used for medicinal purposes. The mulberry root barks, in traditional Chinese medicine name “Sang-Bai-Pi” (White Mulberry Root-Bark) are used for medicinal purposes.

In traditional Chinese medicine, the leaves are considered to be of sweet, bitter and cold properties, which are associated with the liver and lung meridians, and functions to clear lung heat (to manifest as a fever, headache, sore throat or cough) and clear fire in the liver. They are also used to stop bleeding, especially in patients who are vomiting blood. In vitro studies have also shown that decoctions made from fresh mulberry leaves can inhibit the progress of several bacteria, including S. aureus and hemolytics streptococcus. The nearest research shows that mulberry leaves extract with its active compounds glycoprotein (1-Deoxynojirimcin (DNJ)) and polysaccharides, which are a strong Inhibitor of glucosidase I (Ki = 2.1 mM) and II (Ki = 7 mM), can also play a role in the management and treatment of diabetes, and for the same metabolism mechanism, it can also help to control obesity very effectively. The Morus alba leaf extract helps restore the vascular reactivity of diabetic rats. Free radical-induced vascular dysfunction plays a key role in the pathogenesis of vascular disease found in chronic diabetic patients. An ethanolic extract of mulberry leaf had antihyperglycemic, antioxidant and antiglycation effects in chronic diabetic rats, which may suggest its use as food supplement for diabetics. Morus alba plant leaf extract has been studied to process potent antisnake venom property, especially against the local and systemic effects of Daboia russelii venom.

The Mulberry leaf extract used in dietary supplements is derived from the leaves of the plant mulberry trees (Morus alba L.).

Benefits

• Inhibiting activities againstа-glucosidase;

• Inhibiting activities against а-amylase;

• Inhibiting activities against virus;

• Inhibiting activities against tumor metastasis;

• Blood sugar lowering activities;

• Free radical scavenging activities;

• Immune adjustment activities;

• Weight loss activities by prevent absorption of glucose.

• Antisnake venom property

Mechanism

Refer to the above information.

Safety

Mulberry leaf extract is safe, no side effects have been reported to date, but relying on this type of treatment alone, and avoiding conventional medical care, may have serious health consequences.

Dosage

•  The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).
•  Consult physicians for different condition specifics.

GNI’s Mulberry Leaf Extract Features and Benefits:

Mulberry leaf extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Morus alba leaves.

•  Produced with pure water only

•  High purity: over 10%

•  NO solvent - residual free

•  Pesticide-free

•  Browish-Yellow in appearance

•  High solubility in water

•  High anti-bacteria, and longer shelf life

Product Specifications:

0.5%, 1%, 2%, 3%, 10% 1-Deoxynojirimcin (DNJ) HPLC;

15% Polysaccharides UV;

5% Total Flavones UV.